Casodex 150mg Tablet

• Each tablet contains 150 mg bicalutamide
• Each film-coated tablet contains 183 mg of lactose monohydrate

Therapeutic Category
Antiandrogen, Antineoplatic

What is the medicine used for?

• Casodex 150 mg is indicated either alone or as adjuvant to radical prostatectomy or radiotherapy in patients with locally advanced prostate cancer at high risk for disease progression (see section 5.1).
• Casodex 150 mg is also indicated for the management of patients with locally advanced, non-metastatic prostate cancer for whom surgical castration or other medical intervention is not considered appropriate or acceptable.

How does it work?
Bicalutamide is a non-steroidal antiandrogen, devoid of other endocrine activity. It binds to the wild type or normal androgen receptor without activating gene expression, and thus inhibits the androgen stimulus. Regression of prostatic tumours results from this inhibition. Clinically, discontinuation of Casodex can result in the ‘antiandrogen withdrawal syndrome’ in a subset of patients.

How should this medicine be used?

• Adult males including the elderly: The dosage is one 150 mg tablet to be taken orally once a day.
• Casodex 150 mg should be taken continuously for at least 2 years or until disease progression.

Common side effects of the drug
Anaemia, Hypersensitivity, angioedema, urticarial, decreased libido, depression, rash, aloepecia.

What precautions should take when using this medicine?

• Casodex 150 mg is contraindicated in females and children.
• Casodex 150 mg must not be given to any patient who has shown a hypersensitivity reaction to the active substance or to any of the excipients listed

Can I take it with other medicines?
Co-administration of terfenadine, astemizole or cisapride with Casodex is contraindicated.

Are there any food restrictions?
Avoid alcohol intake

How do I store this medicine?
Store at a dry place below 30˚C and away from sunlight

Product Substitutes
Bicalutamide Generic

Manufacturer/Marketer
AstraZeneca

Country of Origin
United Kingdom