Description:

Bioflor 250mg Sachet is a probiotic powder for oral suspension containing lyophilized (freeze-dried) Saccharomyces boulardii CNCM I-745, a beneficial yeast strain. It helps restore and maintain intestinal flora balance, treating acute infectious diarrhea in infants, children, and adults, preventing antibiotic-associated diarrhea, preventing recurrence of Clostridium difficile infections (as adjunct to antibiotics), and preventing tube-feeding-associated diarrhea. It acts through luminal (anti-toxin/anti-adhesion), trophic (gut lining support), and immune-modulating effects without being absorbed into the bloodstream.

Prescription:

• No (available over-the-counter)

Therapeutic Category:

• Probiotic / Anti-Diarrheal / Intestinal Flora Replacement

Active Ingredients/Composition:

• Saccharomyces boulardii CNCM I-745 250 mg (lyophilized yeast cells; minimum 2.5 × 10⁹ CFU per sachet). Excipients: lactose monohydrate, fructose, colloidal anhydrous silica, tutti-frutti flavour (containing sorbitol).

Variant:

• Standard 250 mg powder for oral suspension in sachet (tutti-frutti flavour; very light-brown powder); also available as capsules (250 mg) in the Bioflor line, but this is the sachet variant. Pack sizes include boxes of 10 or 200 sachets.

Consume Type:

• Oral

Directions/Usage:

• Adults and children: 1–2 sachets once or twice daily (up to max 4 sachets/day in divided doses). Infants/children: 1–2 sachets daily (adjust per age/condition). Pour contents into a small amount of water, sweetened beverage, milk, or mix with food (e.g., baby’s bottle). Stir well and drink immediately. Do not mix with very hot (>50°C), very cold/iced, or alcoholic liquids/foods (kills live yeast). Duration typically up to 2 weeks or until symptoms resolve; follow healthcare advice. Rehydration is essential alongside use for diarrhea.

Common Side Effects:

• Generally well-tolerated; mild and rare effects include flatulence (gas), constipation, headache, bloating, or mild GI discomfort. Very rare: allergic reactions (pruritus, urticaria, rash, angioedema), anaphylaxis, or fungemia (yeast in blood). Not known: sepsis in critically ill/immunocompromised patients.

Package Type:

• Paper/aluminum/polyethylene composite sachet (containing light-brown powder); box of 10 sachets

Storage Advice:

• Store away from humidity at a temperature below 30°C (do not refrigerate or freeze). Protect from light and moisture. Keep in original packaging. Do not use after expiry date. Keep out of reach of children.

Safety Advice:

• Contains living yeast cells—do not use with antifungal drugs (oral/systemic) as they kill the probiotic. Contains lactose, fructose, and sorbitol—caution in patients with hereditary fructose intolerance, glucose-galactose malabsorption, or rare lactase deficiency (may cause GI upset). Contraindicated in patients with central venous catheter, critically ill, or immunocompromised (risk of fungemia/sepsis). Not for use in patients with known hypersensitivity to yeast or ingredients. Consult doctor before use in pregnancy (advisable to avoid; limited data) or breastfeeding. If diarrhea persists, worsens, or includes blood/fever, seek medical attention (do not replace rehydration therapy). Report any unusual symptoms (e.g., fever in vulnerable patients) immediately.

Product Substitutes:

• Enterol 250 mg Sachets/Capsules (same Saccharomyces boulardii strain)
• Normagut 250 mg Capsules/Sachets
• Florastor (Saccharomyces boulardii in some markets)
• Other Saccharomyces boulardii probiotics (e.g., generic brands, Ultra-Levure, or local equivalents in Ghana/India like Econorm or Sporlac)
• Similar yeast probiotics for diarrhea prevention

Manufacturer/Marketer:

• Biocodex

Country of Origin:

• France