Description:

Clomipramine 25 mg Capsules TEVA is a generic tricyclic antidepressant (TCA) used primarily to treat obsessive-compulsive disorder (OCD), where it helps reduce recurrent thoughts and repetitive behaviors by increasing serotonin and norepinephrine activity in the brain. It is also used for depression (especially with sedation needs), phobias, and obsessional states. It is the generic equivalent of Anafranil.

Prescription: Prescription-only (Rx). This is a controlled medication requiring a doctor’s prescription due to its potency, side effect profile, and risks (e.g., cardiac effects, suicidality in young patients).

Therapeutic Category:

Tricyclic antidepressant (TCA) / Antiobsessional agent.

Active Ingredients/Composition:

Each capsule contains: Clomipramine hydrochloride 25 mg.

Vitamins: None.

Minerals: None.

Variant: 25 mg strength capsules (other strengths include 10 mg and 50 mg in the TEVA range; this is the standard starting/maintenance strength for many indications).

Consume Type:

Oral (hard gelatin capsule; swallow whole with water, do not crush/chew).

Directions/Usage:

• For OCD/depression/phobias: Start low to minimize side effects—typically 25 mg 1-3 times daily (or 10 mg initially in sensitive patients), gradually increasing over days/weeks to 30-150 mg daily (divided doses or single bedtime dose for better tolerance). Maintenance often 30-50 mg daily, up to max 250 mg in severe cases (hospital-supervised).
• Take with or without food; bedtime dosing reduces daytime sedation.
• Dosage must be individualized by a doctor—do not adjust without guidance. Full effect may take weeks. Gradual taper when stopping to avoid withdrawal. Not for children under certain ages without specialist oversight.

Common Side Effects:

• Anticholinergic: Dry mouth, constipation, blurred vision, urinary retention, sweating
• CNS: Drowsiness/sedation, dizziness, headache, tremor
• GI: Nausea, weight gain/appetite increase
• Cardiovascular: Orthostatic hypotension, tachycardia
• Other: Sexual dysfunction, fatigue Serious/rare: Seizures, QT prolongation/arrhythmias, serotonin syndrome (if combined with other serotonergic), suicidal thoughts (especially in young adults), mania activation. Seek immediate help for severe symptoms like chest pain, confusion, or mood changes.

Package Type:

Blister packs (e.g., 28, 30, 56, 60, or 100 capsules) or HDPE/polypropylene bottles (various counts like 28-1000; not all marketed everywhere). Capsules typically brown cap/orange body (printed e.g., ‘1807’ in some regions) or similar identification.

Storage Advice: Store below 25°C (room temperature), in the original package to protect from light/moisture. Keep out of reach of children.

Safety Advice:

• Risk of suicidality in young adults/children—monitor closely at start/dose changes.
• Cardiac risks: Avoid in recent heart attack, conduction issues; ECG monitoring may be needed.
• Not for use with MAOIs (wait 2-3 weeks washout); caution with SSRIs/other serotonergic (serotonin syndrome risk).
• Avoid alcohol (enhances sedation), driving/machinery if drowsy.
• Caution in elderly, glaucoma, prostate issues, epilepsy, liver/kidney impairment.
• Pregnancy/breastfeeding: Use only if benefits outweigh risks—consult doctor.
• Abrupt stop can cause withdrawal (nausea, headache, irritability)—taper slowly.

Product Substitutes: Other clomipramine brands/generics: Anafranil (original), Apo-Clomipramine, generic clomipramine from various manufacturers (e.g., Mylan/Viatris, Sandoz). For OCD/depression alternatives: SSRIs like fluoxetine, sertraline, fluvoxamine (often first-line now due to better safety profile)—consult psychiatrist for switch.

Manufacturer/Marketer:

Teva Pharmaceutical Industries Ltd. (or Teva UK Limited / Teva Pharma in various regions; manufacturing often by Teva affiliates, e.g., in Hungary or other EU sites).

Country of Origin:

Varies by batch/market—commonly United Kingdom (Teva UK marketing authorization), Hungary (manufacturing site noted in some leaflets), or other EU countries. Generic TEVA products are widely distributed internationally, including in New Zealand, UK, and potentially Africa via importers.