Description

Co-Aprovel is a fixed-dose combination antihypertensive medication used for the treatment of essential hypertension (high blood pressure) in patients whose blood pressure is not adequately controlled by irbesartan or hydrochlorothiazide alone. It combines an angiotensin II receptor blocker (ARB) and a thiazide diuretic.

Prescription

Prescription-only medicine (Rx).

Therapeutic Category

• Cardiovascular agent
• Antihypertensive (Angiotensin II receptor blocker + Thiazide diuretic)

Active Ingredients/Composition

• Irbesartan (ARB):
  • 300 mg or 150 mg 
• Hydrochlorothiazide (HCTZ) (Thiazide diuretic):
  • 12.5 mg

Vitamins

• None

Minerals

• None

Variant

• Tablets available in strengths:
  • Co-Aprovel 150/12.5 mg
  • Co-Aprovel 300/12.5 mg 
• Film-coated tablets
  

Consume Type

• Oral tablets (swallowed with water, with or without food)

Directions/Usage

• Usual adult dose: 1 tablet once daily (either 150/12.5 mg or 300/12.5 mg depending on response).
• May be titrated under medical supervision.
• Take at the same time each day for best results.
• Not recommended in children and adolescents under 18 years.

Common Side Effects

• Dizziness, headache, fatigue
• Nausea, diarrhea, abdominal pain
• Hypotension (low blood pressure)
• Hyperkalemia (high potassium) or hypokalemia (low potassium, due to HCTZ)
• Increased urination
• Rare: allergic skin reactions, angioedema, kidney function changes
  

Package Type

• Blister packs, typically 28 or 30 tablets per carton

Storage Advice

• Store at room temperature (15–30 °C)
• Keep in original blister pack to protect from moisture and light
• Keep out of reach of children
  

Safety Advice

• Avoid in pregnancy and breastfeeding (ARB may harm the fetus).
• Caution in patients with renal impairment, liver disease, or electrolyte imbalance.
• Avoid concomitant use with potassium supplements, potassium-sparing diuretics, or lithium unless closely monitored.
• Regular monitoring of blood pressure, kidney function, and electrolytes is advised.
  
• Avoid excessive alcohol (may enhance hypotensive effect).
  

Product Substitutes

Other ARB + thiazide combinations:

• Co-Diovan (Valsartan + HCTZ)
• Micardis Plus (Telmisartan + HCTZ)
• Hyzaar (Losartan + HCTZ)
• Atacand Plus (Candesartan + HCTZ)
  

Manufacturer/Marketer

• Sanofi-Aventis / Bristol-Myers Squibb (BMS) – original developers and marketers.
  

Country of Origin

• Developed in France/USA (Sanofi & BMS collaboration)
• Manufactured in multiple countries under license (EU, India, others).