Description:

Digoxin 0.125mg is a cardiac glycoside tablet used to treat mild to moderate heart failure (to improve cardiac output and reduce symptoms like shortness of breath and fatigue) and to control the ventricular rate in chronic atrial fibrillation or atrial flutter (to slow the heart rate). It increases the force of heart contractions and slows conduction through the AV node. The 0.125mg strength is commonly used for maintenance therapy, especially in elderly patients or those with reduced renal function.

Prescription:

• Prescription required; consult a physician or cardiologist before use (narrow therapeutic index—requires careful dosing and regular monitoring).

Therapeutic Category:

• Cardiac glycoside / Positive inotropic agent (for heart failure and supraventricular arrhythmias).

Active Ingredients/Composition:

• Digoxin 0.125 mg (125 micrograms) per tablet.

Vitamins: Not present.

Minerals: Not present.

Variant:

• Standard 0.125 mg (125 mcg) tablet (lower maintenance strength; higher strength is usually 0.25 mg / 250 mcg).

Consume Type:

• Oral (tablet form).

Directions/Usage:

Take once daily, at the same time each day, with or without food. Swallow whole with water.

• Adults (maintenance dose): Usually 0.125–0.25 mg (125–250 mcg) daily, adjusted based on age, renal function, serum levels, and response.
  • Elderly / renal impairment: Often 0.0625–0.125 mg daily.
  • Heart failure: Target serum level 0.5–0.9 ng/mL.
  • Atrial fibrillation (rate control): Target 0.8–2 ng/mL. Loading dose (if needed): 0.5–1 mg in divided doses over 24 hours (hospital-supervised). Regular monitoring of serum digoxin levels, electrolytes (especially potassium), renal function, and ECG is essential.

Common Side Effects:

• Nausea, vomiting, loss of appetite, headache, dizziness, fatigue, visual disturbances (yellow/green halos, blurred vision, color changes), confusion, or bradycardia (slow heart rate). Serious (toxicity signs): Arrhythmias, severe nausea/vomiting, confusion, or visual changes—seek immediate medical help.

Package Type:

• Blister strip of 10 or 28 tablets (common pack sizes in Ghana pharmacies).

Storage Advice:

• Store below 30°C in a cool, dry place, protected from light and moisture. Keep in original blister/packaging. Keep out of reach of children.

Safety Advice:

• Contraindicated in ventricular fibrillation, hypertrophic obstructive cardiomyopathy (unless concurrent AF), severe AV block without pacemaker, or known hypersensitivity. Use extreme caution in hypokalemia (greatly increases toxicity), renal impairment (reduce dose), elderly, or with interacting drugs (e.g., verapamil, amiodarone, diuretics, macrolides). Monitor potassium, magnesium, and digoxin levels regularly. Avoid abrupt discontinuation (rebound worsening). Pregnancy: Category C (use only if benefits outweigh risks). Breastfeeding: Passes into milk—monitor infant. Report nausea, vomiting, vision changes, irregular heartbeat, or confusion immediately. Narrow therapeutic index—overdose can be fatal.

Product Substitutes:

• Digoxin 0.125mg generics (Exeter, Vega, or other importers in Ghana)
• Lanoxin 0.125mg (original brand by Aspen in some markets)
• Digon 0.125mg or similar local generics
• Other cardiac glycosides (rarely used alternatives like digitoxin). Consult a cardiologist or doctor for exact alternatives.

Manufacturer/Marketer:

• Briston Laboratories Ltd/Accord Health

Country of Origin:

• India/Uk