Description

Gliclazide 80mg is an oral antidiabetic medication belonging to the sulfonylurea class. It helps control blood sugar levels in adults with type 2 diabetes mellitus (T2DM) by stimulating the pancreas to release more insulin and improving the body’s response to it.

It is typically used when diet, exercise, and weight reduction alone are insufficient to control blood glucose.

Prescription

• Prescription-only medicine .

Therapeutic Category

• Antidiabetic agent / Sulfonylurea (Oral hypoglycemic)

Active Ingredients/Composition

• Gliclazide 80 mg per tablet

Excipients (may vary by brand):

• Lactose monohydrate
• Povidone
• Magnesium stearate
• Hypromellose
• Titanium dioxide (coating agent)

Vitamins

• None

Minerals

• None

Variant

• Gliclazide 80mg (Immediate-release tablets)
• Gliclazide MR (Modified-release) – available in 30mg and 60mg tablets for once-daily use.
• Brands may include:
  • Diamicron® (Servier)
  • Gliclazide Teva / Accord / Mylan / Actavis / Zentiva / Aurobindo (generic versions)

Consume Type

• Oral (tablet, swallowed with water)

Directions/Usage

• Adults:
  • Usual starting dose: 40–80 mg daily, taken once or twice daily before meals.
  • Dose may be gradually increased up to 320 mg daily, divided into 2 doses (morning and evening).
• Modified-release version (MR): usually once daily with breakfast.

Administration:

• Take before meals (preferably breakfast or main meal).
• Swallow whole with water — do not crush or chew MR tablets.
• Follow your doctor’s individualized dosing schedule.

Common Side Effects

Common:

• Mild to moderate hypoglycemia (low blood sugar)
• Headache
• Dizziness
• Nausea
• Stomach upset
  Increased appetite or weight gain

Rare but serious:

• Severe hypoglycemia (confusion, sweating, tremor)
• Liver enzyme elevation or jaundice
• Allergic skin reactions (rash, itching)
  Blood disorders (very rare)

Package Type

• Blister packs of 28 or 56 tablets (standard UK packaging)
• Usually white, round, film-coated tablets

Storage Advice

• Store at room temperature (below 25°C).
• Keep in the original package to protect from moisture and light.
• Keep out of reach of children.

Safety Advice

• Prescription required.
• Monitor blood glucose regularly.
• Avoid skipping meals to prevent hypoglycemia.
• Avoid alcohol, which can increase hypoglycemia risk.
  Inform your doctor if you have kidney or liver disease.
  Not recommended during pregnancy or breastfeeding (unless advised).
• Report unusual fatigue, dizziness, or sweating to your doctor immediately.
• Combine with a balanced diet and regular physical activity.

Product Substitutes

Equivalent or alternative brands available in the UK include:

• Diamicron 80mg Tablets (Servier)
• Gliclazide Accord 80mg Tablets
• Gliclazide Teva 80mg Tablets
• Gliclazide Mylan 80mg Tablets
• Gliclazide Actavis 80mg Tablets
• Gliclazide Zentiva 80mg Tablets
  

Other alternative sulfonylureas:

• Glimepiride (Amaryl)
• Glipizide
• Tolbutamide
  

Manufacturer/Marketer

Several approved manufacturers market Gliclazide 80mg in the UK, including:

• Teva UK Ltd.
• Accord Healthcare Ltd.
• Mylan / Viatris
• Zentiva Pharma UK
  Servier Laboratories Ltd. (original brand: Diamicron)

Country of Origin

• United Kingdom / France (for Servier’s Diamicron brand)