Description:

Gyprone Plus Syrup (Cyproheptadine and Multivitamin Syrup 200ml) is a combination appetite stimulant and nutritional supplement syrup commonly used in children and adolescents. It contains cyproheptadine (an antihistamine with appetite-stimulating properties) combined with a blend of B-complex vitamins and sometimes additional nutrients. It is primarily prescribed or used to improve appetite, promote weight gain, treat poor eating habits, underweight conditions, malnutrition, anorexia, or failure to thrive in children, and support recovery after illness. In Ghana (Accra), it is a very popular, affordable OTC/prescription syrup available in pharmacies for children with low appetite or slow growth.

Prescription: Over-the-counter (OTC) in Ghana for short-term use. No prescription required in most pharmacies; freely available. However, consult a paediatrician or pharmacist before use, especially in children under 2 years, prolonged use, or if poor appetite may be due to underlying medical condition (e.g., infection, malabsorption, or chronic illness).

Therapeutic Category:

Appetite Stimulant + Multivitamin Supplement (Cyproheptadine-based paediatric nutritional tonic for cyproheptadine component).

Active Ingredients/Composition: Per 5 ml (typical formulation):

• Cyproheptadine hydrochloride – 2 mg (appetite stimulant and antihistamine).
• Multivitamins (B-complex group):
  • Thiamine (Vitamin B1) – 2–5 mg
  • Riboflavin (Vitamin B2) – 2–5 mg
  • Niacinamide (Vitamin B3) – 10–20 mg
  • Pyridoxine (Vitamin B6) – 2–5 mg
  • Cyanocobalamin (Vitamin B12) – 5–10 mcg
  • Sometimes added: Lysine hydrochloride (50–100 mg) for protein synthesis/appetite support. Other ingredients: Purified water, sucrose/sorbitol (sweetener), flavoring (e.g., orange/fruit), preservatives, thickeners, citric acid (pH adjuster), and colorants. The syrup is orange/yellow with a pleasant taste.

Vitamins: Yes – B-complex vitamins (B1, B2, B3, B6, B12; sometimes others).

Minerals: None (unless trace amounts in some batches; standard Gyprone Plus has no added minerals like zinc or iron).

Variant:

• Gyprone Plus Syrup 200ml (standard bottle with cyproheptadine + multivitamins). Related variants: Gyprone Syrup (cyproheptadine only), Gyprone Forte (higher potency), smaller bottles (100ml), or syrups with added lysine/zinc (e.g., Apetamin-like formulas). The 200ml bottle is the most common family size.

Consume Type:

Oral – Syrup (liquid; shake well before use; measured with provided spoon/cup).

Directions/Usage: Shake bottle well.

• Children 2–6 years: Typically 2.5–5 ml (½–1 teaspoonful) twice daily.
• Children 7–14 years: 5–10 ml (1–2 teaspoonfuls) twice daily.
• Adults (if prescribed): 10 ml twice daily.
• Take with or after meals to reduce stomach upset.
• Duration: Short-term (2–4 weeks or until appetite improves); do not use longer than 1–2 months without medical advice.
• Combine with balanced diet and encourage regular meals.

Common Side Effects: Common (mainly from cyproheptadine):

• Drowsiness/sedation (most frequent, especially early on).
• Dry mouth.
• Dizziness.
• Increased appetite/weight gain (intended effect).
• Mild gastrointestinal upset (nausea, constipation). Rare: Allergic reactions (rash), blurred vision, or hyperactivity in children. Side effects often decrease after a few days.

Package Type:

Amber plastic bottle of 200ml (with child-resistant cap and measuring spoon/cup; labelled carton with nutritional info, dosing chart, and warnings).

Storage Advice: Store at room temperature (below 25–30°C) in a cool, dry place, away from direct sunlight and heat. Keep tightly closed after use. Out of reach of children.

Safety Advice:

• Use only under medical guidance in children under 2 years or for prolonged periods.
• Contraindicated in glaucoma, urinary retention, prostate enlargement, or known hypersensitivity to cyproheptadine.
• Caution in asthma (may thicken secretions), epilepsy, or liver/kidney impairment.
• Drowsiness may occur – avoid activities requiring alertness (e.g., cycling) until effects are known.
• Do not exceed dose (risk of excessive sedation or weight gain).
• If severe drowsiness, confusion, rash, or no improvement in appetite after 2–3 weeks, stop use and seek medical advice.
• Keep out of reach of children (overdose risk).

Product Substitutes: Similar cyproheptadine + multivitamin syrups in Ghana (often 200ml):

• Apetamin Syrup (cyproheptadine + lysine + vitamins – very popular).
• Periactin Syrup or generic cyproheptadine syrups.
• Astymin-3 Syrup or Kidicare Tonic (multivitamin + lysine – appetite support without cyproheptadine).
• Other local brands like Prowoman/Proman syrups or generic appetite tonics. Consult pharmacist in Accra (e.g., Scab Pharmacy) for availability.

Manufacturer/Marketer:

Opsonin Pharma Ltd. (Bangladesh-based; primary manufacturer of Klabex and many paediatric syrups, but Klabex is clarithromycin; for cyproheptadine + multivitamin syrups, similar products are often from local Ghanaian or Indian manufacturers). Marketed/distributed in Ghana by local importers/pharmacies (widely stocked as imported product).

Country of Origin:

Bangladesh or India (many cyproheptadine + multivitamin syrups like this are manufactured in Bangladesh or India and imported to Ghana).