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Description:
Linezolid is an oxazolidinone class antibiotic used to treat various serious infections caused by Gram-positive bacteria, especially those resistant to other antibiotics (e.g. MRSA, VRE). It is available in a 600 mg oral tablet form. |
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Prescription:Prescription-only. |
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Therapeutic Category:Antibiotic / Oxazolidinone antibacterial agent |
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Active Ingredients/Composition:The active ingredient is linezolid 600 mg per tablet. The tablet also contains inactive excipients (binders, fillers, coatings) specific to the manufacturer. |
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Variant:
The 600 mg strength is a common variant. Linezolid is also available as oral suspension (liquid) and intravenous (IV) formulations. |
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Consume Type:Oral tablet (swallowed with water) |
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Directions/Usage:
- Typical adult dosing: 600 mg every 12 hours (twice daily) for many infections.
- Duration depends on the infection (commonly 10–28 days) as determined by a physician.
- It can be taken with or without food.
- Important: complete full course even if symptoms improve.
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Common Side Effects:
- Gastrointestinal: nausea, diarrhea
- Headache
- Myelosuppression (low blood counts, e.g. thrombocytopenia, anemia) with longer use
- Elevated liver enzymes, possible hepatic effects- Peripheral neuropathy, optic neuropathy (rare, especially with prolonged use)
- Serotonin syndrome risk when combined with serotonergic agents (because linezolid is a weak MAO inhibitor)
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Package Type:Tablets are packaged in blister packs or bottles, labeled appropriately with strength and usage instructions. |
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Storage Advice:Store at room temperature, protected from moisture and light. Keep the container closed. |
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Safety Advice:Do not use for Gram-negative infections (not effective)
Not recommended for use beyond 28 days (safety beyond that is not well established)
Monitor CBC (complete blood counts) regularly due to risk of bone marrow suppression.
Avoid use with adrenergic / serotonergic drugs (SSRIs, TCAs, MAO inhibitors) due to risk of serotonin syndrome or hypertensive reactions.
Use caution in patients with liver disease, renal impairment, or hematologic disorders.
If symptoms worsen or new symptoms arise (e.g. vision changes, neuropathy), stop and consult a physician.
Avoid tyramine-rich foods or supplements when on linezolid (due to MAO inhibition effects) in some settings. |
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Product Substitutes:Generic linezolid branded variants (Zyvox, Zyvoxam, etc.). Alternative antibiotics for Gram-positive resistant infections (depending on sensitivity): vancomycin, daptomycin, tigecycline, etc. |
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Manufacturer/Marketer:Various pharmaceutical companies produce generic linezolid tablets under license. The original brand name is Zyvox (Pfizer) in many markets. |
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Country Origin:The drug development was done by Upjohn (later Pfizer) in the U.S.; generic production is global across many countries. (Linezolid is marketed globally). |
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