Description:
Naloxone Injection 0.4 mg is an opioid antagonist used to rapidly reverse the effects of opioid overdose, including respiratory depression, sedation, and hypotension. It is a life-saving medication used in emergencies and hospital settings.
Prescription:
Prescription Required – Must be administered by or under the direction of a healthcare professional.
Therapeutic Category:
Opioid Antagonist / Antidote
Active Ingredients/Composition:
- Naloxone Hydrochloride – 0.4 mg per 1 ml
Vitamins:
Minerals:
Variant:
- Injection (Parenteral Form)
- Strength: 0.4 mg in 1 ml ampoule or vial
Consume Type:
- Parenteral
- Administered via intravenous (IV), intramuscular (IM), or subcutaneous (SC) injection
Directions/Usage:
- Use only under medical supervision
- In emergency cases of suspected or confirmed opioid overdose
- Dosage may be repeated at 2–3 minute intervals as needed
- Onset of action: within 2 minutes (IV), slightly longer for IM/SC
Common Side Effects:
- Nausea and vomiting
- Sweating
- Increased blood pressure
- Tremors or seizures (rare)
- Agitation or irritability
- Return of opioid withdrawal symptoms in dependent individuals (e.g., anxiety, diarrhea, body aches)
Package Type:
- Glass ampoule or vial
- Also available in prefilled syringes or auto-injectors in some markets (e.g., Evzio)
Storage Advice:
- Store between 15°C and 25°C
- Protect from light and heat
- Do not freeze
- Keep out of reach of children
Safety Advice:
- Not effective against non-opioid drug overdoses
- Should be used with caution in opioid-dependent patients due to withdrawal risk
- Short half-life: may require repeated doses or continuous infusion
- Always seek emergency medical help after administration
Product Substitutes:
(Some commonly available brands/formulations)
- Narcan (Pfizer or Emergent Biosolutions)
- Naloxone Sandoz
- Nalone (Neon)
- Nalox (Samarth)
- Evzio (auto-injector, USA)
Manufacturer/Marketer:
- Multiple manufacturers depending on the brand, including:
- Samarth Life Sciences
- Neon Laboratories
- Pfizer
- Sandoz
- Verve Human Care (in some cases)
Country of Origin:
- Typically India (for Indian brands)
- Also manufactured in the USA, Germany, and other countries for global brands
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