•  Cardiovascular agent
•  Selective β₁-blocker / Antihypertensive
•  (Also used in heart failure settings in some guidelines)

•  Nebivolol hydrochloride 5 mg per tablet (as the active ingredient)
•  Excipients include lactose monohydrate, polysorbate 80, hypromellose, maize starch, microcrystalline cellulose, croscarmellose sodium, colloidal silica, magnesium stearate. 

•  5 mg strength (as in Nebilet 5 mg)
•  Other strengths of nebivolol exist (2.5 mg, 10 mg, etc.) under brand/generic names. 

•  Usual dose for hypertension is 5 mg once daily (taken at the same time every day). 
•  May be increased gradually by physician if needed (often every 2 weeks) up to a maximum (e.g. 40 mg for nebivolol in some regimens) 
•  Can be taken with or without food. 
•  In heart failure (especially in older patients), lower starting doses and careful titration are used. 
•  Do not stop abruptly; tapering may be required under supervision. 

Headache, dizziness, fatigue/tiredness 

•  Swelling (peripheral edema) 
•  Slow heart rate (bradycardia) 
•  Gastrointestinal symptoms: nausea, diarrhea, abdominal discomfort 
•  Respiratory effects in predisposed individuals (cough, shortness of breath) in sensitive patients with lung disease
•  Possible masking of hypoglycemia signs in diabetics
•  Less commonly, sexual dysfunction, sleep disturbances, etc.
•  Rare but serious: hypotension, heart block, bronchospasm in susceptible individuals, exacerbation of heart failure in decompensated states

Tablets typically come in blister packs (e.g. 14 or 28 tablets) in cartons. Example: Nebilet 5 mg 14 tablets blister pack. 

•  Use caution in asthma or obstructive lung disease (may precipitate bronchospasm) 
•  Use cautiously with conduction abnormalities or use of other heart rate-lowering drugs
•  Monitor heart rate, blood pressure, renal and hepatic function during therapy
•  In diabetics, be aware that beta blockers can mask signs of hypoglycemia (e.g. tachycardia) 
•  Avoid abrupt discontinuation — taper gradually to prevent rebound hypertension or ischemic events
•  Use in pregnancy only if benefit justifies risk; avoid or closely monitor in breastfeeding (< safety data)
•  Interaction caution: many drug interactions, especially with CYP2D6 substrates/inhibitors
•  Contains lactose — patients with lactose intolerance should consider that. 

Other beta-blockers: metoprolol, atenolol, bisoprolol

In hypertension management, alternative classes depending on patient: ACE inhibitors, ARBs, calcium channel blockers, etc.

Many generic manufacturers also produce nebivolol products.