Description:

Neflucon Fluconazole Suspension 10mg/ml (50ml) is a paediatric-friendly oral antifungal medication. It treats and prevents fungal infections, including oropharyngeal candidiasis (thrush), esophageal candidiasis, cryptococcal meningitis, candidemia, and other invasive candidiasis in children and adults who cannot swallow tablets. It is also used for prophylaxis in immunocompromised patients (e.g., neutropenia). Fluconazole inhibits fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, disrupting ergosterol synthesis in fungal cell membranes.

Prescription: Prescription-only (Rx). Requires a doctor’s prescription (typically from a paediatrician or infectious disease specialist) with diagnosis confirmation (e.g., culture for candidiasis).

Therapeutic Category:

Antifungal / Triazole antifungal (systemic azole for candidiasis and cryptococcosis).

Active Ingredients/Composition:

Each ml of reconstituted suspension contains: Fluconazole 10 mg (10 mg/ml). Total in 50ml bottle: 500 mg fluconazole (powder for reconstitution with water to 50 ml). Excipients: Sucrose (sweetener), sodium benzoate (preservative), citric acid, sodium citrate, xanthan gum, titanium dioxide, orange flavor, colloidal silicon dioxide (standard for fluconazole suspensions; refer to label for full list).

Vitamins: None.

Minerals: None.

Variant: 10 mg/ml oral suspension in 50 ml bottle (powder form requiring reconstitution; paediatric strength; differs from 40 mg/ml adult-focused suspensions or tablets/capsules).

Consume Type:

Oral (reconstituted suspension; measured with spoon/syringe; shake well before each dose).

Directions/Usage: Reconstitution: Add specified volume of water (usually ~45 ml to make 50 ml), shake vigorously to disperse powder. Dosage (weight-based for children; adult/older child use per doctor):

• Oropharyngeal candidiasis: 6 mg/kg on Day 1 (max 200 mg), then 3 mg/kg daily (max 100 mg) for ≥2 weeks.
• Oesophageal candidiasis: 6 mg/kg Day 1 (max 200 mg), then 3 mg/kg daily (max 100 mg) for ≥3 weeks + 2 weeks after symptoms resolve.
• Systemic candidiasis/cryptococcal: Higher loading/maintenance doses (6-12 mg/kg daily, max 800 mg). Take once daily; can be with/without food. Complete full course. Follow specialist instructions; not for self-adjustment.

Common Side Effects:

• Gastrointestinal: Nausea, vomiting, diarrhoea, abdominal pain
• Headache
• Rash
• Liver enzyme elevation
• Rare: Allergic reactions (rash, swelling), QT prolongation, Stevens-Johnson syndrome Most mild/transient; monitor liver function in prolonged use.

Package Type:

Plastic bottle of 50 ml (powder form; child-resistant cap; often with measuring device and reconstitution instructions; carton box).

Storage Advice: Store unreconstituted powder at room temperature (below 25-30°C), protected from moisture/light. After reconstitution: Refrigerate (2-8°C) and use within 14-28 days (per label; shake before use). Keep out of reach of children.

Safety Advice:

• For fungal infections only—ineffective for bacterial/viral illnesses.
• Contraindicated in hypersensitivity to fluconazole/azoles or with drugs prolonging QT (e.g., certain antiarrhythmics).
• Caution in severe liver/renal impairment (dose adjustment), history of QT prolongation, or electrolyte disturbances.
• Risk of hepatotoxicity—monitor liver enzymes; discontinue if severe.
• Pregnancy: Use if benefits outweigh risks (Category D in high doses; teratogenic potential). Breastfeeding: Caution (excreted in milk).
• Interactions: Warfarin (increased bleeding), statins (myopathy risk), rifampin (reduced efficacy).
• Report severe rash, jaundice, dark urine, or irregular heartbeat promptly.
• Complete course to prevent resistance.

Product Substitutes: Other fluconazole suspensions (10 mg/ml or 40 mg/ml) in Ghana: Diflucan Suspension (Pfizer), generic fluconazole suspension (various importers), or brands like Flucostat. Alternatives: Voriconazole or itraconazole suspensions for resistant cases—consult paediatrician/infectious disease specialist.

Manufacturer/Marketer:

Pharm Inter (likely Pharm Inter or associated importer/distributor; product imported generic). Manufactured by a generic Indian company (common for such suspensions in Ghanaian market).

Country of Origin:

India.