Description:

Ofloxacin Tablets IP 200mg is a synthetic fluoroquinolone antibiotic used to treat a variety of bacterial infections in adults. It is effective against susceptible Gram-positive and Gram-negative bacteria, including infections of the urinary tract, respiratory tract (e.g., bronchitis, pneumonia), skin and soft tissues, gastrointestinal tract, female genital organs, and other systemic infections. It inhibits bacterial DNA gyrase and topoisomerase IV enzymes, preventing DNA replication and causing cell death. It is reserved for infections where other antibiotics may be ineffective or contraindicated.

Prescription: Prescription-only (Rx). Requires a doctor’s prescription due to risks of tendon damage, nerve issues, and antibiotic resistance. In Ghana and similar markets, it is regulated and available through pharmacies.

Therapeutic Category:

Antibacterial / Fluoroquinolone antibiotic (broad-spectrum for systemic bacterial infections).

Active Ingredients/Composition:

Each film-coated tablet contains: Ofloxacin IP 200 mg. Excipients: Standard tablet components (e.g., starch, cellulose, magnesium stearate, film-coating agents; refer to label for full list—no additional actives).

Vitamins: None.

Minerals: None.

Variant: 200 mg strength film-coated tablets (standard dose; pack of 20×10 tablets [200 tablets total] in blister/Alu-Alu packaging common in listings; yellow PVC blister noted in some sources).

Consume Type:

Oral (tablet; swallow whole with a full glass of water; can be taken with or without food, but avoid dairy/antacids near dose as they reduce absorption).

Directions/Usage: Adults: Dosage varies by infection type and severity (follow doctor’s exact prescription; standard guidelines):

• Most infections (e.g., urinary tract, skin, respiratory): 200-400 mg every 12 hours for 3-14 days.
• Uncomplicated cystitis: 200 mg every 12 hours for 3-7 days.
• Bronchitis/pneumonia: 400 mg every 12 hours for 10 days.
• Gonorrhoea/urethritis/cervicitis: 300-400 mg single dose or every 12 hours for 7 days. Take at regular intervals; complete full course even if symptoms improve to prevent resistance. Adjust in renal impairment (reduce dose if CrCl <50 mL/min). Not for children unless specialist-directed.

Common Side Effects:

• Nausea, vomiting, diarrhoea, abdominal pain
• Headache, dizziness, sleep problems (insomnia)
• Rash, itching
• Vaginal itching/discharge (vaginitis)
• Less common: Fatigue, photosensitivity (sun sensitivity) Serious rare: Tendonitis/tendon rupture (especially Achilles), peripheral neuropathy (nerve damage), QT prolongation/arrhythmias, severe allergic reactions, low blood sugar, C. difficile diarrhoea. Seek immediate help for tendon pain/swelling, numbness/tingling, irregular heartbeat, or severe diarrhoea.

Package Type: Blister packs (often 20×10 tablets [200 tablets total]; yellow PVC blister or Alu-Alu strips in carton box).

Storage Advice: Store at room temperature (below 25-30°C), in a cool, dry place away from direct sunlight, heat, and moisture. Keep in original packaging. Keep out of reach of children.

Safety Advice:

• High risk of serious side effects (FDA black box warnings): tendon rupture (higher in elderly, corticosteroids), peripheral neuropathy (may be permanent), CNS effects (seizures, mood changes), hypoglycaemia.
• Contraindicated in known hypersensitivity to fluoroquinolones, myasthenia gravis (exacerbation risk), or with tizanidine.
• Caution in elderly, renal impairment (dose reduce), history of seizures, QT prolongation, or low potassium/magnesium.
• Avoid in pregnancy/breastfeeding unless essential (arthropathy risk in fetus).
• Avoid excessive sun exposure (photosensitivity).
• Interactions: Antacids/dairy/iron reduce absorption (space 2 hours); warfarin (increased bleeding); NSAIDs (increased CNS effects).
• Stop immediately if tendon pain, nerve symptoms, severe rash, or mental changes occur.
• Complete course to prevent resistance; report persistent/worsening symptoms.

Product Substitutes: Other ofloxacin 200mg tablets in Ghana: Offneck-200 (same John Lee brand), generic ofloxacin (various importers), or brands like Oflox (Cipla), Tarivid (Sanofi). Alternatives: Levofloxacin, ciprofloxacin, or non-fluoroquinolones (e.g., cefixime, amoxicillin-clavulanate) per infection/sensitivity—consult doctor/pharmacist (reserve fluoroquinolones for resistant cases per guidelines).

Manufacturer/Marketer:

John Lee Pharmaceuticals Pvt. Ltd. (Indian pharmaceutical company; produces Offneck-200 as ofloxacin 200mg tablets). Marketed/distributed in Africa (including Ghana) via local importers/pharmacies.

Country of Origin:

India.