Description

A topical triple-combination cream that merges:

• Betamethasone (a potent corticosteroid)—reduces inflammation, redness, and itching.
• Clotrimazole (an antifungal)—treats fungal skin infections.
• Gentamicin (an antibiotic)—targets and inhibits bacterial infections.
  

Used for skin conditions that involve inflammation plus fungal and/or bacterial involvement, such as infected eczema, psoriasis with secondary infection, tinea corporis/cruris/pedis complicated by secondary bacterial infection. 

2. Prescription

Typically Prescription-only (Rx/POM). Available OTC only in limited cases and regions. 

3. Therapeutic Category

• Topical corticosteroid
  Combined with antifungal and antibacterial agents.
  

Categorized under dermatological combination therapy for anti-inflammatory, antifungal, and antibacterial action. 

4. Active Ingredients / Composition

Typical concentrations (per gram of cream):

• Betamethasone dipropionate: ~0.025%–0.05%
• Clotrimazole: 1%
• Gentamicin sulfate: ~0.1% 

5. Vitamins

None.

6. Minerals

None.

7. Variant

• Available as topical cream in tubes (~15–30 g).
• No other variants (e.g., ointments, lotions) commonly used.

8. Consume Type

• Topical application only—for external use on affected skin.
• Avoid eyes, mucous membranes, open wounds, and lesions. 

9. Directions / Usage

• Apply a thin layer over the affected area twice daily (morning and evening).
• Continue for 1–4 weeks depending on the severity.
• If no improvement by 3–4 weeks, consult a healthcare provider.
  

10. Common Side Effects

• Local irritation: burning, stinging, itching, redness, dryness, peeling.
• Rare but serious: skin thinning (atrophy), stretch marks, telangiectasia, hypo/hyperpigmentation, allergic contact dermatitis.
• Systemic risks (with prolonged/large-area use): adrenal suppression, hyperglycemia, ototoxicity, nephrotoxicity (gentamicin risk).

11. Package Type

• Typically in metal or laminated tubes of around 15–30 g. 

12. Storage Advice

• Store in a cool, dry place, protected from direct sunlight.
• Keep out of reach of children.

13. Safety Advice

• Contraindications: Hypersensitivity to any component; viral skin infections (e.g., herpes), varicella, tuberculosis; rosacea, acne, perioral dermatitis; application on open wounds or ulcerated lesions.
  Precautions: Avoid use under occlusion unless directed. Children are more susceptible to systemic steroid effects. Use cautiously in infants. 
• Pregnancy/Breastfeeding: Use only when benefits outweigh risks. Avoid applying near breasts if breastfeeding. 
• Avoid prolonged use, especially on extensive areas or under occlusion. Monitor diabetic patients and those on other nephrotoxic or ototoxic drugs.
  

14. Product Substitute

Other triple-combination creams available under various brand names depending on region:

• Aristoderm CG
• Bet-CG
• Gentaprox
• Combiderm
• Triderm, etc.

15. Manufacturer / Marketer

Since “S‑Betrigen” isn’t found in databases, here are examples of similar products:

• Gentaprox Cream by Hanbet Pharmaceuticals Ltd, made by Health Care Formulations Pvt. Ltd (India). 
• Another formulation by KNOX Pharmaceutical Nig Ltd, manufactured by Claroid Pharmaceuticals Pvt. Ltd (India).

16. Country of Origin

• Most generic or similar combination creams are manufactured in India, often for import into African markets including Ghana.