Description:
Silvederma Cream is a topical antibacterial agent containing silver sulfadiazine, primarily used for the prevention and treatment of infections in burn wounds. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, as well as some fungi, making it suitable for various types of skin injuries and ulcers, especially burns.

Prescription:
Yes, Silvederma Cream is a prescription-only medicine (POM).

Therapeutic Category:
Topical Antibiotic (ATC code: D06BA01) 

Active Ingredients/Composition:
Each 100 g of cream contains 1 g of silver sulfadiazine. Vitamins:
None

Minerals:
None

Variant:
1% strength cream, available in a 50 g tube.

Consume Type:
Topical application

Directions/Usage:

• Clean and debride the wound before application.

• Apply the cream using sterile gloves to cover the affected area with a thickness of approximately 1 to 3 mm.

• Typically applied once or twice daily.

• Continue treatment until satisfactory healing is achieved or until the wound is ready for grafting.

• Dressings are optional but may be used for patient comfort.

Common Side Effects:

• Local reactions such as burning, itching, or rash.

• Leukopenia (a decrease in white blood cells), which is usually reversible upon discontinuation.

• Skin discoloration (argyria) with prolonged use.

• Rare systemic effects, especially when applied to large areas, including blood disorders and allergic reactions. 

Package Type:
Polyethylene tube with a turning cap containing 50 g of cream. 

Storage Advice:

• Store below 30°C.

• Protect from light.

• Keep out of reach of children.

Safety Advice:

• Contraindicated in patients hypersensitive to sulfonamides or any component of the preparation.

• Not recommended for use in premature infants or newborns under two months due to the risk of kernicterus.

• Use with caution in patients with significant hepatic or renal impairment.

• Monitor for signs of systemic absorption when applied to large areas or for prolonged periods.

Product Substitutes:
Other brands containing silver sulfadiazine 1% include:

• Flamazine

• Silvadene

• Dermazin

Manufacturer/Marketer:
Laboratorio ALDO-UNIÓN, S.L., located at Baronesa de Maldá, 73, 08950 Esplugues de Llobregat, Barcelona, Spain. 

Country of Origin:
Spain