Description:

Skycid (Omeprazole Sodium for Injection 40mg) is a sterile, lyophilized powder for reconstitution and intravenous administration. It is a proton pump inhibitor (PPI) that reduces gastric acid secretion by irreversibly blocking the H+/K+ ATPase enzyme in parietal cells. It serves as an alternative to oral omeprazole therapy when oral intake is inappropriate (e.g., in hospitalized patients, severe conditions, or inability to swallow). It is used for treating peptic ulcers (duodenal/gastric), reflux esophagitis, NSAID-associated ulcers, H. pylori eradication (with antibiotics), symptomatic GERD, and Zollinger-Ellison syndrome. Widely available in Ghanaian pharmacies and hospitals.

Prescription:

Prescription-only (requires a doctor’s prescription; administered by healthcare professionals in clinical settings, such as hospitals or clinics in Accra).

Therapeutic Category:

Proton Pump Inhibitor (PPI) / Anti-ulcer Agent / Gastric Acid Suppressant (for intravenous use

Active Ingredients/Composition:

• Active ingredient: Omeprazole (as Omeprazole Sodium) – 40 mg per vial (equivalent to omeprazole base).
• Pharmaceutical form: White or almost white crystalline hygroscopic powder for solution for infusion. Other ingredients: Typically includes stabilizers like disodium edetate or sodium hydroxide (for pH adjustment); may come with Water for Injection (WFI) ampoule for reconstitution in some packs (check label).

Vitamins:

None.

Minerals:

None (trace sodium from omeprazole sodium salt, but not a mineral supplement).

Variant:

• Skycid 40mg Injection (standard single vial, often with WFI). No major variants noted under Skycid branding; similar to other omeprazole IV generics (e.g., 40mg vials from other importers in Ghana).

Consume Type:

Parenteral – Intravenous (IV) infusion (reconstitute powder with solvent, then infuse slowly; not for oral or IM use).

Directions/Usage:

Administered only by healthcare professionals. Reconstitute as per instructions (typically with 10ml WFI or compatible solvent to make a clear solution).

• Standard dose (alternative to oral): 40 mg IV once daily, infused over 20-30 minutes.
• Zollinger-Ellison syndrome: Initial 60 mg IV daily (may increase and divide if >60 mg).
• Special populations: No adjustment for renal impairment/elderly; reduce to 10-20 mg daily in severe hepatic impairment. Limited pediatric data. Transition to oral therapy when possible. Follow hospital protocols exactly.

Common Side Effects:

Generally well-tolerated; similar to oral omeprazole but may include injection-site reactions. Common:

• Headache
• Abdominal pain, nausea, diarrhea, constipation, flatulence
• Dizziness
• Injection site pain/redness Other: Rash, dry mouth. Rare/serious (seek immediate help): Severe allergic reactions, severe hypomagnesemia (long-term), fractures (long-term high-dose), Clostridium difficile infection, visual disturbances.

Package Type:

Single glass vial (containing 40mg powder) ± ampoule of Water for Injection (WFI); often sold as 1 vial per pack (e.g., 1’s in Ghanaian pharmacies).

Storage Advice:

Store unreconstituted vials below 25-30°C in a cool, dry place, protected from light and moisture. After reconstitution, use immediately or as per stability data (usually within hours; do not store reconstituted solution long-term). Keep out of reach of children.

Safety Advice:

• For IV use only under medical supervision.
• Contraindicated if hypersensitivity to omeprazole, benzimidazoles, or excipients.
• Caution in severe liver impairment, osteoporosis risk (long-term), or pregnancy/breastfeeding (consult doctor).
• Monitor for hypomagnesemia, infections, or fractures with prolonged use.
• May interact with drugs like clopidogrel, warfarin, diazepam—inform doctor of all medications.
• Not for self-administration.

Product Substitutes:

Other omeprazole 40mg IV injections available in Ghana include:

• Generic omeprazole sodium for injection (various importers, e.g., from India/China).
• Brands like Osec 40, Omezol, or similar PPI IVs (e.g., pantoprazole IV like Pantoloc/Pantop).
• For acid suppression: Ranitidine IV (if appropriate), but PPIs preferred for many indications. Consult a pharmacist or doctor in Accra for availability and suitability.

Manufacturer/Marketer:

Manufactured by Pharmax India Pvt. Ltd. (India); Marketed/Distributed in Ghana by Eskay Therapeutics Ltd. (Accra, Ghana; address: 42 South Industrial Area, P.O. Box 431, Darkuman, Accra).

Country of Origin:

India