Description:

Testosterone Enanthate Injection Testonos-Depot 250 (by John Lee) is a long-acting injectable androgen hormone replacement therapy. It is used primarily to treat hypogonadism (low testosterone levels) in adult men, restoring normal serum testosterone, improving libido, sexual function, muscle mass, bone density, mood, energy, and secondary sexual characteristics. It is also used in certain delayed puberty cases in boys and off-label for other androgen deficiency states. The enanthate ester provides sustained release over 2–4 weeks after intramuscular injection. In Ghana (Accra), it is a prescription controlled medication available in select pharmacies and hospitals for testosterone replacement under specialist supervision.

Prescription:

Prescription-only (strictly prescription-only in Ghana; requires a doctor’s prescription, typically from an endocrinologist, urologist, or physician after confirming low testosterone via blood tests; dispensed with monitoring of haematocrit, PSA, liver function, and testosterone levels; classified as a controlled/anabolic steroid; not OTC).

Therapeutic Category:

Androgen / Anabolic Steroid / Hormone Replacement Therapy (Long-acting testosterone ester.

Active Ingredients/Composition:

• Active ingredient: Testosterone Enanthate – 250 mg per 1 ml (250 mg/ml oily solution). Other ingredients: Benzyl benzoate (solvent), castor oil or arachis (peanut) oil (carrier oil for depot release), benzyl alcohol (preservative). The solution is clear, pale yellow to yellow, sterile, and oil-based for slow intramuscular release.

Vitamins: None.

Minerals: None.

Variant:

• Testonos-Depot 250 (standard 250 mg/ml strength; common vial/ampoule size 1 ml or 10 ml multi-dose vial). Related variants: Testosterone Enanthate 100 mg/ml (lower strength), other esters (e.g., testosterone cypionate 200–250 mg/ml, testosterone undecanoate), or combination products (rare). The 250 mg/ml is the most common strength for replacement therapy.

Consume Type:

Injectable – Intramuscular (IM) injection (deep IM into gluteal muscle or vastus lateralis; administered by healthcare professional or self-administered after training; slow injection to minimize pain).

Directions/Usage: Administered only as prescribed (usually by IM injection).

• Adult men with hypogonadism: Typical dose 250 mg IM every 2–4 weeks (most common 250 mg every 3–4 weeks).
• Dose and frequency adjusted individually based on serum testosterone levels (target mid-normal range), symptoms, and tolerability.
• Shake vial/ampoule well if multi-dose.
• Use sterile technique; rotate injection sites.
• Duration: Long-term (often lifelong) for hypogonadism; regular endocrine monitoring required (testosterone, haematocrit, PSA, lipids every 3–6 months).
• Do not exceed prescribed dose.

Common Side Effects: Common:

• Injection site pain, swelling, or irritation.
• Acne, oily skin, increased body hair.
• Weight gain (fluid retention or muscle).
• Gynecomastia (breast enlargement in men).
• Mood changes (irritability, aggression).
• Increased haematocrit/erythrocytosis (thick blood).
• Decreased sperm count/infertility (suppression of natural testosterone). Rare/serious (seek help): Prostate enlargement (monitor PSA), liver toxicity (rare with injectables), cardiovascular events (hypertension, thrombosis risk), sleep apnea, or severe allergic reactions.

Package Type:

Glass ampoule or multi-dose vial of 1 ml or 10 ml (containing 250 mg/ml solution; ampoules in packs of 5–10; vials with rubber stopper; labelled carton with instructions and warnings).

Storage Advice: Store at room temperature (below 25–30°C) in original packaging, protected from light. Do not freeze. Keep out of reach of children.

Safety Advice:

• Administered only under medical supervision (risk of polycythaemia, prostate issues, cardiovascular events, and suppression of natural testosterone).
• Contraindicated in hypersensitivity to testosterone, prostate/breast cancer (men), severe heart/liver/kidney disease, or pregnancy (fetal harm).
• Caution in elderly (increased prostate/cardiac risk), sleep apnea, or bleeding disorders.
• Regular monitoring required (testosterone levels, haematocrit, PSA, lipids, liver function).
• Do not use for bodybuilding/performance enhancement (illegal in many contexts; serious health risks).
• If chest pain, shortness of breath, leg swelling, severe acne, jaundice, or mood changes occur, seek immediate care.
• Keep out of reach of children (overdose risk).

Product Substitutes: Similar testosterone enanthate 250 mg/ml injections in Ghana include:

• Generic testosterone enanthate 250 mg/ml (various importers).
• Testoviron Depot (Bayer/Schering original brand if stocked).
• Test E or other local generics. Alternatives: Testosterone cypionate 200–250 mg/ml (Depo-Testosterone), testosterone undecanoate (Nebido – longer-acting), or testosterone gel/patches (for replacement therapy). Consult endocrinologist/urologist in Accra for alternatives.

Manufacturer/Marketer:

John Lee (India-based pharmaceutical company; produces Testonos-Depot as part of its injectable steroid range). Marketed/distributed in Ghana by local importers/pharmacies (widely stocked as imported generic).

Country of Origin:

India (manufactured by John Lee; imported to Ghana and available in local pharmacies/hospitals).