Description:

Adenosine Injection IP Carnosin 6mg/2ml by SAMARYTH (Samarth Life Sciences) is a sterile, fast-acting antiarrhythmic medication used primarily for the emergency conversion of paroxysmal supraventricular tachycardia (PSVT) to sinus rhythm. It works by slowing conduction through the AV node and interrupting re-entrant circuits in the heart. It is also used as a diagnostic aid during cardiac stress testing or myocardial perfusion imaging.

Prescription: Prescription-only (Rx). This is a hospital/emergency-use injectable requiring administration by trained healthcare professionals (e.g., in ER, ICU, or cardiac unit) under continuous ECG monitoring. Not for self-administration.

Therapeutic Category:

Antiarrhythmic agent (Class V, endogenous nucleoside) / Diagnostic aid for cardiac stress testing.

Active Ingredients/Composition:

Each 2 ml vial contains: Adenosine 6 mg (3 mg/ml). Excipients: Sodium chloride (for isotonicity) and Water for Injection (sterile, non-pyrogenic solution).

Vitamins: None.

Minerals: None (sodium chloride is for tonicity, not therapeutic mineral).

Variant: 6 mg/2 ml (3 mg/ml) single-dose vial (standard adult starting dose strength; higher strengths like 30 mg/10 ml exist for other uses or brands).

Consume Type:

Intravenous (IV) injection only – rapid bolus push followed by saline flush; never intramuscular, subcutaneous, or oral.

Directions/Usage: Administered only by healthcare professionals in a monitored setting (ECG, resuscitation equipment available). For PSVT conversion (adults):

• Initial dose: 6 mg (2 ml) as rapid IV bolus over 1-2 seconds, immediately followed by 20 ml saline flush.
• If no conversion within 1-2 minutes: Second dose 12 mg (4 ml) rapid bolus.
• Third dose (if needed): Another 12 mg.
• Paediatric dosing: Weight-based (e.g., 0.1 mg/kg initial, max 6 mg; 0.2 mg/kg subsequent, max 12 mg). For diagnostic use (stress testing): Continuous infusion protocol per guidelines. Do not dilute; use undiluted. Patient should be supine; monitor for asystole or bradycardia post-dose.

Common Side Effects:

• Flushing, chest pain/discomfort/pressure (common, transient)
• Dyspnoea/shortness of breath, throat tightness
• Headache, dizziness, nausea
• Bradycardia, AV block, hypotension (usually brief)
• Facial warmth, palpitations Most resolve within seconds to minutes due to short half-life (~10 seconds). Serious: Prolonged asystole, ventricular fibrillation (rare)—requires immediate intervention.

Package Type: Single-dose glass vial of 2 ml (often in packs of 1, 5, or 10 vials; sterile, clear solution).

Storage Advice: Store at room temperature (15-30°C), protected from light. Do not refrigerate or freeze. Keep out of reach of children. Use immediately after opening; discard unused portion.

Safety Advice:

• Administer only in facilities equipped for cardiac resuscitation (defibrillator, atropine, etc.).
• Contraindicated in second/third-degree AV block (without pacemaker), sick sinus syndrome, asthma/COPD (bronchospasm risk), hypersensitivity.
• Caution in heart transplant patients (prolonged effect), elderly, or those on dipyridamole (potentiates adenosine—reduce dose).
• Avoid caffeine/theophylline/xanthines (antagonize effect—may require higher dose).
• Monitor ECG continuously; warn patient of transient chest pain/dyspnea.
• Pregnancy/breastfeeding: Use if clearly needed (Category C).
• Not for atrial fibrillation/flutter conversion (may cause rapid ventricular response if WPW present).

Product Substitutes: Other adenosine injections (same strength): Adenocor, Adenosine Injection IP (generic from Sun Pharma, Neon, etc.), Astyfer Adenosine, or branded versions like Adenocard. Equivalent generics from Cipla, Intas, or other Indian manufacturers. In some markets, imported adenosine from Teva or Hospira.

Manufacturer/Marketer:

Samarth Life Sciences Pvt. Ltd. (also listed as Samarth Pharma or SAMARYTH in some contexts).

Country of Origin:

India.