Description:

Amoksiclav 625mg Tablets (by Sandoz) is a combination antibiotic containing amoxicillin (a broad-spectrum penicillin) and clavulanic acid (a beta-lactamase inhibitor). It treats bacterial infections caused by susceptible organisms, particularly those resistant to amoxicillin alone due to beta-lactamase production. Common indications include respiratory tract infections (e.g., sinusitis, otitis media, pneumonia, bronchitis exacerbations), urinary tract infections, skin/soft tissue infections, dental infections, and bone/joint infections. The 625mg strength (500mg amoxicillin + 125mg clavulanic acid) is a standard adult dose for moderate infections, providing twice-daily dosing. In Ghana (Accra), Sandoz Amoksiclav 625mg is a widely available, affordable prescription antibiotic in pharmacies (e.g., Scab Pharmacy, Country Medical Pharmacy, Beybee Pharmacy, Meldinpharma).

Prescription:

Prescription-only (requires a doctor’s prescription in Ghana; dispensed by pharmacies with Rx to confirm bacterial infection and appropriate use, avoiding misuse/resistance).

Therapeutic Category:

Penicillin Antibiotic + Beta-Lactamase Inhibitor Combination (Broad-spectrum antibacterial for beta-lactamase producing organisms.

Active Ingredients/Composition:

Each film-coated tablet contains:

• Amoxicillin (as amoxicillin trihydrate) – 500 mg
• Clavulanic acid (as potassium clavulanate) – 125 mg Total 625 mg co-amoxiclav per tablet. Other ingredients (excipients, typical): Microcrystalline cellulose, sodium starch glycolate, colloidal anhydrous silica, magnesium stearate, hypromellose, titanium dioxide (E171), macrogol, and talc (film-coating). Tablets are white to off-white, oval, film-coated.

Vitamins: None.

Minerals:

None (trace potassium from potassium clavulanate, but not therapeutic).

Variant:

• Amoksiclav 625mg Film-Coated Tablets (standard 500/125 mg strength; common pack sizes 10, 14, or 20 tablets). Related variants: Amoksiclav 375mg (250/125 mg for milder cases), Amoksiclav 1g (875/125 mg for severe infections), Amoksiclav Suspension (pediatric forms), or dispersible tablets. The 625mg is the most common adult oral dose.

Consume Type:

Oral – Film-coated tablet (swallow whole with water; take at the start of a meal to reduce GI upset).

Directions/Usage:

Take as prescribed (usually twice daily every 12 hours).

• Adults and children >40 kg: Typically 1 tablet (625 mg) every 12 hours (twice daily).
• For more severe infections: May be increased to 1 tablet every 8 hours (three times daily) if advised.
• Duration: 5–14 days depending on infection (e.g., 7–10 days for sinusitis/bronchitis; complete full course).
• Take with food to minimize stomach upset.
• Use measuring device for suspension if prescribed.

Common Side Effects: Common:

• Diarrhea (most frequent)
• Nausea, vomiting
• Abdominal pain
• Rash, itching
• Candidiasis (thrush) Other: Headache, dizziness. Serious (seek immediate help): Severe diarrhea (C. difficile), allergic reactions (rash/swelling/anaphylaxis), liver issues (jaundice), or severe skin reactions.

Package Type:

Blister packs (commonly 10 or 14 tablets per strip, packs of 1×10, 1×14, or 2×10 = 10–28 tablets; foil blisters in carton with patient information leaflet).

Storage Advice:

Store below 25–30°C in a cool, dry place, away from direct sunlight, heat, and moisture. Keep in original packaging, tightly closed. Do not freeze. Out of reach of children.

Safety Advice:

• Only for bacterial infections (ineffective against viruses).
• Contraindicated if allergic to penicillins/cephalosporins/clavulanic acid, or history of liver issues with this combo.
• Caution in severe liver/kidney impairment (dose adjustment), glandular fever (higher rash risk), or history of antibiotic-associated colitis.
• Inform doctor if pregnant/breastfeeding (generally safe but confirm), or on anticoagulants (may increase bleeding risk).
• If severe rash, breathing difficulty, or persistent diarrhea occurs, stop and seek urgent care.
• Complete course to prevent resistance; probiotics may help prevent diarrhea.

Product Substitutes: Similar co-amoxiclav (amoxicillin/clavulanic acid) 625mg tablets in Ghana include:

• Generic co-amoxiclav 625mg (various importers).
• Augmentin (GSK original brand, higher price).
• Other brands like Amoklavin, Bioclavid, or local generics (e.g., Amoksiklav Sandoz). Alternatives: Amoxicillin alone, cefuroxime, or other antibiotics (consult doctor for infection/sensitivity). Available at pharmacies like Scab Pharmacy, Country Medical Pharmacy in Accra.

Manufacturer/Marketer:

Sandoz (a division of Novartis/Sandoz group; Sandoz is the global generic manufacturer for Amoksiclav). Marketed/distributed in Ghana by local importers/pharmacies (e.g., Scab Pharmacy Limited, Meldinpharma).

Country of Origin:

Slovenia or India (Sandoz generics often manufactured in Lek Pharmaceuticals Slovenia or Indian facilities; imported to Ghana as affordable option).