Description:

Amovulin Suspension  is a paediatric antibiotic oral suspension containing amoxicillin and clavulanic acid (co-amoxiclav). It treats bacterial infections caused by susceptible organisms, particularly those resistant to amoxicillin alone due to beta-lactamase production. Common indications include respiratory tract infections (e.g., otitis media, sinusitis, tonsillitis, pneumonia), urinary tract infections, skin/soft tissue infections, and dental infections in children. The 228.5mg/5ml strength (200mg amoxicillin + 28.5mg clavulanic acid per 5ml) is a lower-dose formulation suitable for paediatric use.

Prescription:

Prescription-only.

Therapeutic Category:

Penicillin Antibiotic + Beta-Lactamase Inhibitor Combination (Broad-spectrum antibacterial for beta-lactamase producing organisms in pediatrics.

Active Ingredients/Composition:

After reconstitution, per 5 ml:

• Amoxicillin (as amoxicillin trihydrate) – 200 mg
• Clavulanic acid (as potassium clavulanate) – 28.5 mg Total 228.5 mg co-amoxiclav per 5 ml. Other ingredients (excipients, typical): Sucrose/sorbitol (sweetener), flavoring (e.g., fruit), preservatives (e.g., sodium benzoate), suspending agents, thickeners, citric acid (pH adjuster), and purified water (dry powder for reconstitution).

Vitamins: None.

Minerals: None (trace potassium from potassium clavulanate, but not therapeutic).

Variant:

• Amovulin 228.5mg Suspension (standard paediatric strength; common bottle size 70ml or 100ml after reconstitution). Related variants: Amovulin 457mg Suspension (400mg amoxicillin + 57mg clavulanic acid per 5ml for higher-dose paediatric or adult use), or Amovulin tablets/capsules. The 228.5mg/5ml is the lower-dose paediatric variant.

Consume Type:

Oral – Powder for oral suspension (reconstitute with water to make liquid; shake well before each dose; measured with provided syringe/spoon).

Directions/Usage:

Reconstitute powder with specified boiled/cooled water volume (follow bottle instructions; usually ~65–95 ml for final volume). Shake vigorously.

• Children: Dose based on body weight (typically 20–40 mg/kg/day amoxicillin equivalent, divided every 8–12 hours; doctor determines exact). Example: 5–10 ml twice or three times daily depending on weight/severity.
• Take at start of meals to reduce stomach upset.
• Duration: Usually 5–10 days (complete full course even if symptoms improve).
• Use measuring device (not household spoon).
• Store reconstituted suspension in refrigerator.

Common Side Effects: Common:

• Diarrhoea (most frequent)
• Nausea, vomiting
• Abdominal pain
• Rash, itching
• Candidiasis (thrush) Other: Headache, dizziness. Serious (seek immediate help): Severe diarrhoea (C. difficile), allergic reactions (rash/swelling/anaphylaxis), liver issues (jaundice), or severe skin reactions.

Package Type:

Amber plastic bottle (powder for reconstitution to 70ml or 100ml; child-resistant cap, measuring syringe/spoon included; often in carton with leaflet).

Storage Advice:

• Before reconstitution: Store dry powder below 25–30°C in cool, dry place, away from light/moisture.
• After reconstitution: Refrigerate (2–8°C); do not freeze. Use within 7–14 days (check label). Shake well before each dose. Out of reach of children.

Safety Advice:

• Only for bacterial infections (ineffective against viruses).
• Contraindicated if allergic to penicillins/cephalosporins/clavulanic acid, or history of liver issues with this combo.
• Caution in severe liver/kidney impairment (dose adjustment), glandular fever (higher rash risk), or history of antibiotic-associated colitis.
• Inform doctor if pregnant/breastfeeding (generally safe but confirm), or on anticoagulants (may increase bleeding risk).
• If severe rash, breathing difficulty, or persistent diarrhoea occurs, stop and seek urgent care.
• Complete course to prevent resistance; probiotics may help prevent diarrhoea.

Product Substitutes: Similar co-amoxiclav suspensions in Ghana (228.5mg/5ml or equivalent) include:

• Generic amoxicillin/clavulanic acid 200/28.5mg per 5ml (various importers).
• Augmentin ES (GSK paediatric brand, similar strength).
• Other brands like Amoklavin, Bioclavid, or local generics. Alternatives: Amoxicillin alone, cefuroxime suspension, or other paediatric antibiotics (consult doctor for infection/sensitivity). Available at pharmacies like Scab Pharmacy, Country Medical Pharmacy in Accra.

Manufacturer/Marketer:

Tobinco Pharmaceuticals Limited (TPL; Ghana-based pharmaceutical company; produces Amovulin as part of its antibiotic range). Marketed/distributed locally in Ghana by Tobinco (address: Tobinco Pharmaceuticals Ltd., Accra).

Country of Origin:

Ghana (manufactured locally by Tobinco Pharmaceuticals Limited; widely stocked in Accra pharmacies as a local product).