Description:

Chlorpromazine 25mg/ml Injection is a typical (first-generation) antipsychotic medication used to treat severe psychiatric disorders such as schizophrenia, mania in bipolar disorder, acute psychosis, severe agitation, and intractable hiccups. It is also used as an antiemetic (to control severe nausea and vomiting) and for preoperative sedation. It works by blocking dopamine receptors in the brain and has additional anticholinergic, antihistaminic, and alpha-adrenergic blocking effects.

Prescription:

• Prescription required; administered only by healthcare professionals (intramuscular or intravenous under supervision).

Therapeutic Category:

• Antipsychotic / Phenothiazine (typical/first-generation antipsychotic; also antiemetic and sedative).

Active Ingredients/Composition:

• Chlorpromazine hydrochloride 25 mg per mL (in sterile aqueous solution). Other ingredients: Ascorbic acid, sodium metabisulfite, sodium sulfite, sodium chloride, and Water for Injection (may vary slightly by manufacturer; contains sulfites).

Variant: S

• tandard 25 mg/mL strength in ampoules or vials (1 mL or 2 mL); commonly available as 25 mg/mL for IM/IV use.

Consume Type:

• Parenteral (intramuscular deep injection preferred; intravenous only when diluted and under strict medical supervision).

Directions/Usage: Administered by a doctor/nurse only.

• Psychosis/agitation: 25–50 mg IM every 3–4 hours as needed (max initial 100 mg/day; titrate carefully).
• Nausea/vomiting: 25 mg IM/IV every 4–6 hours as needed.
• Preoperative sedation: 12.5–25 mg IM 1–2 hours before surgery. Dilute IV doses in compatible fluid (e.g., 0.9% NaCl); never give undiluted IV. Rotate injection sites to avoid tissue damage.

Common Side Effects:

• Drowsiness/sedation, dry mouth, blurred vision, constipation, urinary retention, orthostatic hypotension, extrapyramidal symptoms (tremor, rigidity, akathisia), tardive dyskinesia (with long-term use), weight gain, photosensitivity, and nasal congestion. Serious: Neuroleptic malignant syndrome, severe hypotension, QT prolongation, agranulocytosis, seizures, or anaphylaxis.

Package Type:

• Single-dose ampoule (1 mL or 2 mL containing 25 mg/mL) or multi-dose vial; usually packed in boxes of 5–25 ampoules.

Storage Advice:

• Store below 30°C, protected from light (discoloration may occur if exposed). Do not freeze. Keep in original packaging. Keep out of reach of children. Discard if solution is discolored or contains particles.

Safety Advice:

• Contraindicated in coma, severe CNS depression, bone marrow depression, severe hypotension, or known hypersensitivity (including sulfite allergy). Use extreme caution in elderly (risk of falls), Parkinson’s disease, epilepsy, glaucoma, prostatic hypertrophy, or cardiovascular disease. Monitor for extrapyramidal symptoms, QT prolongation, and blood dyscrasias. Avoid alcohol and other CNS depressants. Pregnancy: Category C (use only if benefits outweigh risks). Breastfeeding: Avoid (passes into milk). Report fever, muscle rigidity, confusion, or severe allergic reactions immediately. Not for subcutaneous use.

Product Substitutes:

• Largactil Injection (original brand by GSK)
• Chlorpromazine HCl Injection generics (e.g., from Eugia, Hikma, AdvaCare, or other importers)
• Thorazine Injection (in some markets)
• Other typical antipsychotics (e.g., haloperidol injection) if substituted by doctor. Consult a doctor/pharmacist for alternatives.

Manufacturer/Marketer:

• Distributed by Scab Pharmacy Limited

Country of Origin:

• Ghana