Description:

S-Preb 75mg capsules (Pregabalin and Methylcobalamin Capsules) is a combination medication used to treat neuropathic pain (nerve pain) associated with diabetic peripheral neuropathy, postherpetic neuralgia (pain after shingles), spinal cord injury, and other peripheral/central neuropathic conditions. It may also be used as adjunctive therapy for partial seizures in epilepsy and for generalized anxiety disorder (GAD) in adults. Pregabalin reduces pain signals from damaged nerves by binding to calcium channels in the CNS, while methylcobalamin (active vitamin B12) supports nerve regeneration and myelin sheath repair.

Prescription: Prescription-only (Rx). Requires a doctor’s prescription (typically from a neurologist, diabetologist, or pain specialist) with assessment of neuropathic pain and monitoring for side effects (e.g., sedation, weight gain).

Therapeutic Category:

Neuropathic pain reliever / Anticonvulsant + neurotrophic vitamin combination (for peripheral/central neuropathic pain equivalent for pregabalin component).

Active Ingredients/Composition:

Each hard gelatin capsule contains:

• Pregabalin BP 75 mg
• Methylcobalamin USP 750 mcg (0.75 mg) Excipients: Standard capsule fillers (e.g., approved colors for capsule shells, q.s.; refer to label for full list).

Vitamins: Yes – Methylcobalamin (active form of Vitamin B12).

Minerals: None.

Variant: Hard gelatin capsules (75 mg pregabalin + 750 mcg methylcobalamin; standard combination strength; pack of 10 capsules common in listings).

Consume Type:

Oral (capsule; swallow whole with water; can be taken with or without food).

Directions/Usage: Adults: Typical dose 1 capsule twice daily (150 mg pregabalin + 1.5 mg methylcobalamin total daily), or as prescribed (dose range 150-600 mg pregabalin/day in divided doses). Take at regular intervals; full effect may take weeks. Do not exceed recommended dose. Follow doctor’s instructions; not for children unless specialist-directed. Regular monitoring for efficacy and side effects (e.g., dizziness, weight gain).

Common Side Effects:

• Dizziness, drowsiness, somnolence
• Dry mouth
• Blurred vision
• Weight gain
• Peripheral edema (swelling in hands/feet)
• Headache
• Fatigue
• Gastrointestinal upset (nausea, constipation) Rare: Mood changes, confusion, allergic reactions (rash, swelling).

Package Type:

Blister packs (typically 10 capsules per strip; 1-3 strips in carton box with leaflet).

Storage Advice: Store at room temperature (below 25-30°C), in a cool, dry place away from direct sunlight, heat, and moisture. Keep in original packaging. Keep out of reach of children.

Safety Advice:

• May cause drowsiness/dizziness—avoid driving/machinery or alcohol.
• Caution in severe renal impairment (dose reduction), heart failure, or history of depression.
• Not for children without specialist advice.
• Pregnancy/breastfeeding: Use only if benefits outweigh risks (limited data).
• Monitor for weight gain, edema, or mood changes.
• Report severe dizziness, vision changes, or allergic symptoms promptly.
• Not for acute pain—use for chronic neuropathic conditions.

Product Substitutes: Other pregabalin + methylcobalamin capsules in Ghana: Prebax (Panacea), Pregaba-M (Unichem), Prebalyn (Panacea), or generics (e.g., Pregabalin 75mg + Methylcobalamin 750mcg from various importers). Separate pregabalin (Lyrica generics) + vitamin B12 supplements may substitute. Consult doctor/pharmacist for equivalents.

Manufacturer/Marketer:

Panacea Pharmaceuticals Ltd

Country of Origin:

Ghana.