Description:

Coveram 5/10mg 30 tablets is a fixed-dose combination antihypertensive medication containing perindopril (an ACE inhibitor) and amlodipine (a calcium channel blocker). It is used to treat essential hypertension (high blood pressure) in adults when blood pressure is not adequately controlled with either medicine alone. The combination provides additive blood pressure lowering by relaxing blood vessels through two different mechanisms.

Prescription:

Prescription-only.

Therapeutic Category:

ACE Inhibitor + Calcium Channel Blocker Combination (Fixed-dose antihypertensive).

Active Ingredients/Composition: Each film-coated tablet contains:

• Perindopril arginine – 5 mg
• Amlodipine besilate – equivalent to 10 mg amlodipine Other ingredients (excipients, typical): Lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, macrogol, and iron oxides (for coloring). Tablets are white to off-white, round, film-coated, and debossed with strength.

Vitamins: None.

Minerals: None.

Variant:

• Coveram 5mg/10mg tablets (this specific strength combination). Related variants: Coveram 5/5mg, 10/5mg, 10/10mg (different dose combinations). The 5/10mg strength is commonly used when higher amlodipine effect is needed alongside perindopril.

Consume Type:

Oral – Film-coated tablet (swallow whole with water; do not crush or chew).

Directions/Usage:

• Adults: 1 tablet once daily.
• Can be taken with or without food.
• Take at the same time each day for consistent blood pressure control.
• Duration: Long-term (often lifelong) for hypertension; do not stop suddenly without medical advice (rebound hypertension risk).
• Regular monitoring of blood pressure, renal function, and electrolytes (especially potassium) is required.

Common Side Effects: Common:

• Peripheral edema (ankle/foot swelling – mainly from amlodipine).
• Cough (from perindopril – ACE inhibitor cough).
• Headache.
• Dizziness or light headedness.
• Fatigue.
• Flushing (from amlodipine). Rare/serious (seek help): Angioedema (swelling of face/lips/throat – rare but serious with ACE inhibitors), severe hypotension, acute kidney injury, or severe allergic reactions.

Package Type:

Blister packs (typically 30 tablets per pack; foil blisters in carton with patient information leaflet and dosing guide).

Storage Advice: Store at room temperature (below 25–30°C) in original packaging, protected from moisture and light. Keep tightly closed. Out of reach of children.

Safety Advice:

• Contraindicated in pregnancy (fetal toxicity – stop immediately if pregnancy occurs), hypersensitivity to perindopril, amlodipine, or other ACE inhibitors/dihydropyridines, history of angioedema, or severe renal impairment.
• Caution in bilateral renal artery stenosis, heart failure, aortic stenosis, or volume depletion.
• Monitor renal function and potassium levels regularly (especially when starting or increasing dose).
• Report immediately: swelling of face/lips/tongue/throat, severe dizziness, persistent dry cough, or signs of infection.
• Avoid potassium supplements or potassium-sparing diuretics without monitoring.
• Keep out of reach of children (overdose risk).

Product Substitutes: Similar perindopril + amlodipine combination tablets in Ghana include:

• Generic perindopril/amlodipine 5mg/10mg tablets (various importers).
• Coveram (original Servier brand – same product).
• Alternatives: Amlodipine + losartan, amlodipine + valsartan, or separate perindopril + amlodipine taken together. Consult cardiologist/physician in Accra for alternatives.

Manufacturer/Marketer:

Servier (original developer and brand holder of Coveram). Marketed/distributed in Ghana by Servier Ghana or local importers/pharmacies (widely stocked).

Country of Origin:

France.