Description:

Gvither Plus 80/480 Tablet  is a fixed-dose combination antimalarial medication used for the treatment of acute, uncomplicated malaria caused by Plasmodium falciparum in adults and children weighing 35 kg and above. It combines artemether (a fast-acting artemisinin derivative that rapidly reduces parasite load) with lumefantrine (a longer-acting partner drug that clears remaining parasites and prevents recrudescence). This artemisinin-based combination therapy (ACT) is highly effective and helps reduce the risk of resistance development.

Prescription: Prescription-only (Rx). Requires a doctor’s prescription and confirmed malaria diagnosis (e.g., via rapid diagnostic test or microscopy) before use, following national malaria treatment guidelines.

Therapeutic Category:

Antimalarial / Artemisinin-based combination therapy (ACT).

Active Ingredients/Composition: Each tablet contains:

• Artemether 80 mg
• Lumefantrine 480 mg

Vitamins: None.

Minerals: None.

Variant: High-strength adult formulation: 80 mg artemether / 480 mg lumefantrine per tablet (standard for patients ≥35 kg; lower strengths like 20/120 mg exist for children).

Consume Type:

Oral (tablet; swallow whole with water; must be taken with food or fatty milk to improve absorption of lumefantrine).

Directions/Usage: Standard 3-day regimen (6 doses total) for adults and children ≥35 kg:

• Day 1: 4 tablets as a single initial dose, followed by 4 tablets after 8 hours.
• Day 2: 4 tablets twice daily (morning and evening).
• Day 3: 4 tablets twice daily (morning and evening). Total: 24 tablets over 3 days. Take with food or fatty milk to enhance absorption. Complete the full course even if symptoms improve. If vomiting occurs within 1 hour of a dose, repeat that dose. Follow national malaria guidelines or doctor’s instructions.

Common Side Effects:

• Headache
• Dizziness
• Loss of appetite, nausea, vomiting
• Fatigue/weakness
• Abdominal pain
• Muscle/joint pain
• Fever or chills (may be due to malaria itself) Most are mild and resolve after treatment. Serious but rare: QT prolongation (heart rhythm changes), severe allergic reactions, or neurological effects.

Package Type:

Blister pack of 6 or 24 tablets (often supplied as complete treatment courses; 24 tablets for adult full course).

Storage Advice: Store at room temperature (below 30°C), in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.

Safety Advice:

• Must be taken with food/fatty substance for proper absorption.
• Not for severe or complicated malaria (requires injectable treatment or hospital care).
• Avoid in patients with known hypersensitivity, severe heart conditions, or concurrent use of drugs that prolong QT interval.
• Consult doctor if pregnant (generally used in second/third trimester when benefits outweigh risks), breastfeeding, liver/kidney impairment, or on other medications.
• Complete full course to prevent resistance and recurrence.
• Monitor for worsening symptoms or signs of allergy.

Product Substitutes: Other artemether/lumefantrine 80/480 mg combinations: Coartem (Novartis original), Lumartem, Duomal Forte, or generic AL (artemether-lumefantrine) tablets. Other ACTs (e.g., artesunate-amodiaquine) may be alternatives per local guidelines. Consult a doctor or pharmacist based on national malaria protocols.

Manufacturer/Marketer:

Bliss GVS Pharma Ltd. (Indian pharmaceutical company). Marketed/distributed in Ghana and Africa via local importers or Bliss GVS affiliates.

Country of Origin:

India.