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Neostigmine  Injection 10mg/20ml

Neostigmine  Injection 10mg/20ml

Neostigmine is an anticholinesterase agent used to reverse the effects of non-depolarizing neuromuscular blocking agents after surgery and to treat conditions like myasthenia gravis and postoperative urinary retention. It increases the levels of acetylcholine at neuromuscular junctions by inhibiting acetylcholinesterase.

Price: 120.00

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Product description

Description:

Neostigmine is an anticholinesterase agent used to reverse the effects of non-depolarizing neuromuscular blocking agents after surgery and to treat conditions like myasthenia gravis and postoperative urinary retention. It increases the levels of acetylcholine at neuromuscular junctions by inhibiting acetylcholinesterase.

Prescription:

  • Yes, Neostigmine is a prescription-only medication.

Therapeutic Category:

  • Cholinesterase Inhibitor

  • Reversal Agent (Neuromuscular Blockade Reversal)

  • Parasympathomimetic Agent

Active Ingredients/Composition:

  • Neostigmine Methylsulfate 10 mg/20 mL
    (Concentration: 0.5 mg/mL)

Vitamins:

  • None

Minerals:

  • None

Variant:

  • Typically available as:

    • 10 mg/20 mL multi-dose vial

    • Also available in ampoules (e.g., 0.5 mg/mL in 1 mL or 5 mL ampoules)

Consume Type:

  • Parenteral (Intramuscular, Intravenous, or Subcutaneous injection)

  • Administered only by healthcare professionals

Directions/Usage:

  • Reversal of neuromuscular blockade: Given IV, typically alongside an anticholinergic (e.g., atropine or glycopyrrolate) to counteract muscarinic side effects.

  • Myasthenia gravis: Dosage individualized, can be given IM or SC.

  • Dose and administration route depend on clinical condition and patient response.

  • Must be administered under close medical supervision.

Common Side Effects:

  • Nausea and vomiting

  • Abdominal cramps

  • Bradycardia

  • Increased salivation

  • Bronchial secretions

  • Muscle cramps

  • Sweating

  • Rare: Heart block, hypotension, or allergic reactions

Package Type:

  • Glass vials or ampoules

  • Commonly in multi-dose vials (20 mL)

  • Packed in boxes with a package insert

Storage Advice:

  • Store at 15°C to 25°C (59°F to 77°F)

  • Protect from light

  • Do not freeze

  • Use within specified period after opening (refer to label)

Safety Advice:

  • Use with caution in patients with:

    • Asthma, bradycardia, or recent coronary occlusion

    • Peptic ulcer or peritonitis

  • Contraindicated in mechanical intestinal or urinary obstruction

  • Anticholinergic (e.g., atropine) often co-administered to prevent muscarinic effects

  • Monitor heart rate, respiratory function, and muscarinic side effects during use

  • Use during pregnancy only if clearly needed

Product Substitutes:

  • Pyridostigmine Bromide (longer-acting alternative for myasthenia gravis)

  • Edrophonium (for diagnostic use in myasthenia gravis)

  • Other brands of Neostigmine from different manufacturers (generic equivalents)

Manufacturer/Marketer:

  • Pfizer, Baxter, Cipla, Neon Laboratories, Fresenius Kabi, Samarth Life Sciences, and others depending on region.

Country of Origin:

  • Varies by manufacturer.

    • Brand examples:

      • Pfizer/Baxter – USA

      • Cipla/Neon – India

      • Fresenius Kabi – Germany

 

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