Description:
Rabies Antiserum Immunoglobulin 1000 IU/5 mL is a sterile solution containing rabies-specific antibodies. It provides immediate passive immunity by neutralizing the rabies virus at the site of exposure, serving as a critical component in post-exposure prophylaxis (PEP) for individuals potentially exposed to rabies.
Prescription:
Dosage:
- The recommended dose is 20 IU per kilogram of body weight.
- For a 70 kg adult, this equates to 1,400 IU, or 7 mL of the solution.
- As much of the dose as anatomically feasible should be infiltrated around and into the wound(s).
- Any remaining volume should be administered intramuscularly at a site distant from the vaccine administration site.
- Administration should occur as soon as possible after exposure, ideally within 24 hours, and no later than 7 days after the first dose of rabies vaccine.
Therapeutic Category:
- Immunoglobulin / Passive Immunization Agent
Active Ingredients/Composition:
- Rabies Immunoglobulin derived from human plasma or equine serum, standardized to 1000 IU per 5 mL vial.
Variant:
- Available as a 5 mL vial containing 1000 IU of rabies immunoglobulin.
Consume Type:
- Parenteral — Administered via infiltration into and around the wound and intramuscular injection.
Directions/Usage:
- Wound Care: Immediately and thoroughly cleanse all bite wounds and scratches with soap and water.
- Administration: Infiltrate as much of the calculated dose as anatomically feasible into and around the wound(s). Any remaining volume should be administered intramuscularly at a site distant from the rabies vaccine injection site.
- Combination with Vaccine: Rabies immunoglobulin should be used in conjunction with a full course of rabies vaccine.
Common Side Effects:
- Pain at the injection site
- Fever
- Headache
- Nausea
- Allergic reactions, including rash or, rarely, anaphylaxis
Package Type:
- Supplied in glass vials, each containing 5 mL of solution equivalent to 1000 IU of rabies immunoglobulin.
Storage Advice:
- Store at 2°C to 8°C (36°F to 46°F).
- Do not freeze.
- Protect from light.
Safety Advice:
- Not recommended for individuals with known hypersensitivity to human immunoglobulins or any component of the formulation.
- Use with caution in individuals with a history of allergic reactions to blood products.
- Not indicated for individuals who have previously received a complete rabies vaccination series and have adequate antibody titers.
Product Substitutes:
- Rabix-IG (Incepta Pharmaceuticals Ltd.)
- Favirab (Synovia Pharma PLC.)
- Rabivax-IG (Popular Pharmaceuticals Ltd.)
Manufacturer/Marketer:
- Incepta Pharmaceuticals Ltd.
Country of Origin:
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