Amiodarone injection contains Amiodarone, an antiarrhythmic agent indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy.
Why do you need this medication? Amiodarone injection contains Amiodarone, an antiarrhythmic agent indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy.
Each ml contains 50 mg of amiodarone hydrochloride
Each 3 ml ampoule contains 150 mg amiodarone hydrochloride
Excipient with known effect: 60.6 mg of benzyl alcohol/ampoule of 3 ml sterile concentrate
DOSAGE AND ADMINISTRATION
Routes of administration: Intravenous use
Amiodarone injection can be used where a rapid response is required or where oral administration is not possible.
The standard recommended loading dose is 5 mg/kg bodyweight in 250 ml of 5% dextrose infused within 20 minutes to 2 hours. This may be repeated 2 to 3 times during the following 24 hours (up to 1200 mg/24 hours [approximately 15 mg/kg bodyweight] in up to 500 ml 5% dextrose) and the rate of infusion is to be controlled according to the clinical response.
In extreme clinical emergency the drug may, at the discretion of the clinician, be given as a slow injection of 150-300 mg in 10-20 ml 5% dextrose over a minimum of 3 minutes, dose should be given from a pre-filled syringe or diluted in 20ml Glucose 5%.
Amiodarone should only be used in a special care unit under continuous monitoring (ECG and blood pressure).
WARNINGS AND PRECAUTIONS
Amiodarone is only to be used when other anti-arrhythmics have shown insufficient effect.
Intravenous injection is generally not recommended due to the haemodynamic risk (severe hypotension, circulatory collapse), and intravenous infusion is to be preferred where possible.
POSSIBLE SIDE EFFECTS
The most common adverse reactions (1-2%) leading to discontinuation of intravenous amiodarone therapy are hypotension, asystole/cardiac, arrest/pulseless electrical activity, VT, and cardiogenic shock
Other important adverse reactions are, torsade de pointes (TdP), congestive heart failure, and liver function test abnormalities.
Store in a refrigerator (2°C to 8°C)
Store in the original package in order to protect from light.