Description
S‑Vox 500 mg is a film‑coated oral tablet containing levofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various serious bacterial infections when first‑line options are unsuitable or ineffective .
2. Prescription
This medication is prescription-only (Rx) internationally.
3. Therapeutic Category
Falls under antibacterial agents, specifically the fluoroquinolone (quinolone) class, used for systemic infections.
4. Active Ingredients / Composition
- Active: Levofloxacin hemihydrate equivalent to 500 mg levofloxacin per tablet .
- Excipients: Include microcrystalline cellulose, crospovidone, hypromellose, PEG-400, titanium dioxide, and colorants .
5. Vitamins
None included.
6. Minerals
None included.
7. Variant
This product is the 500 mg film-coated tablet. Other strengths exist (e.g., 250 mg), but S‑Vox refers to the 500 mg only.
8. Consume Type
Oral use: film‑coated tablet taken by mouth.
9. Directions / Usage
Dosage depends on infection type and severity:
- Typical dosing (renal function normal):
- 500 mg once daily, or twice daily for some infections like pneumonia.
- Examples by condition:
| Condition |
Dose & Duration |
| Acute sinusitis, bronchitis exacerbation |
500 mg once daily – 7–14 days |
| Community-acquired pneumonia |
500 mg once or twice daily – 7–14 days |
| Pyelonephritis, skin infections |
500 mg once daily – 7–14 days |
| Chronic prostatitis |
500 mg once daily – up to 28 days |
| Uncomplicated cystitis |
250 mg once daily – 3 days (note lower dose) |
-
- Renal impairment: Dose adjusted based on creatinine clearance .
- Administration: Take with or without food, at the same time each day; swallow whole with water.
10. Common Side Effects
- Common: nausea, diarrhea, headache, dizziness, insomnia, constipation, trouble sleeping.
- Serious: tendon rupture or inflammation, peripheral neuropathy, CNS effects (confusion, psychosis), QT prolongation, photosensitivity, risk of aortic aneurysm rupture or dissection, and dysglycemia (especially in diabetics).
- Drug-associated C. difficile–associated diarrhea, with potential severity.
11. Package Type
Typically provided in blister packs (e.g., 1, 5, or 10 tablets per pack).
12. Storage Advice
- Store below 25 °C in original blister packaging.
- Keep dry and away from light.
- Keep out of reach of children.
13. Safety Advice
- Monitor for tendon pain or neurologic symptoms; discontinue immediately if these occur.
- Avoid excessive sun exposure and use protective measures during treatment and up to 48 hours after.
- Be cautious with concurrent corticosteroids—risk of tendon problems increases.
- Avoid in patients with epilepsy, QT prolongation, severe aortic pathology, or history of psychiatric illnesses .
- Interactions: do not co-administer within 2 hours of antacids, iron, zinc supplements, didanosine, sucralfate, etc., as absorption can be significantly reduced.
- May increase effects of warfarin (monitor INR).
- Avoid alcohol due to potential effect on CNS side effects.
- Not generally recommended in children due to musculoskeletal risks, except in serious cases such as anthrax exposure.
- Pregnancy/breastfeeding: use only if benefits justify risk; limited data with low apparent risk.
14. Product Substitute
Generic equivalents of levofloxacin 500 mg are widely available under various brand names (e.g., Levaquin, Tavanic) and by numerous manufacturers.
15. Manufacturer / Marketer
Details on “S‑Vox” specifically weren’t located in sources. However, generic levofloxacin 500 mg tablets in the UK are marketed by Ipca Laboratories UK Ltd, and an unnamed “Indian Research Laboratory” appears in one retail listing
16. Country of Origin
Likely India or UK depending on manufacturing source. E.g., Ipca (UK) version is made in the UK
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