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Potassium Citrate Mixture

Potassium Citrate Mixture

An oral alkalinizing solution combining potassium citrate and citric acid, used to relieve urinary discomfort (“dysuria”) in mild urinary tract infections and to alkalinize urine in conditions like gout, kidney stones (uric acid or cystine), and renal tubular acidosis

Price: 12.00

Key Product Information

Oral care, Saliva substitute, Moisturizer.

tropical spray

Potassium citrate 1-2% Glycerin  Xylitol  Water  Flavorings

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Product description

Description

An oral alkalinizing solution combining potassium citrate and citric acid, used to relieve urinary discomfort (“dysuria”) in mild urinary tract infections and to alkalinize urine in conditions like gout, kidney stones (uric acid or cystine), and renal tubular acidosis .

Prescription

Prescription-only in most countries, including the UK, since it contains high levels of potassium and requires medical supervision .

 Therapeutic Category

Systemic and urinary alkalizing agent – urinary alkalinizer for urology and metabolic indications .

Active Ingredients / Composition

  • Potassium citrate 1.5 g per 5 mL (pure solution) 
  • Citric acid (as monohydrate) ~334 mg per 5 mL (stabilizes pH) 

Inactive excipients include sucrose (~1.1 g/5 mL), sodium benzoate, and trace ethanol.

 Vitamins

None.

 Minerals

Potassium citrate contributes significant potassium ions (~20–30 mEq per dose); no other minerals.

Variant

A solution (mixture) available in bottles (commonly 100–200 mL). Variants include sugar-free or citrate+sodium citrate combinations, but the standard formulation is potassium citrate + citric acid.

Consume Type

Oral solution. Must be diluted in a glass of water before use. Shake before each dose .

Directions / Usage

  • Adults & children ≥6 years: 10 mL (2 teaspoonfuls) diluted 3 times daily after meals . 
  • Children 1–6 years: 5 mL diluted 3 times daily after meals . 
  • Duration: until urinary symptoms resolve; for stone prevention or metabolic acidosis, long-term dosing per physician.

 Common Side Effects

  • Mild nausea or occasional vomiting due to gastric irritation 
  • Potential hyperkalemia in susceptible patients: symptoms include weakness, tingling, confusion

Package Type

Typically supplied in amber glass or plastic bottles, with measuring cap or spoon. Common sizes include 100–200 mL. The UK SmPC refers to mixture for oral use.

Storage Advice

  • Store at room temperature, ideally ≤25 °C (or per local label) 
  • Keep bottle tightly closed, away from excessive heat or freezing 
  • Discard any unused portion 2 months after opening 

Safety Advice

  • Contraindicated: hyperkalemia, renal impairment, Addison’s disease, cardiac arrhythmias 
  • Use with caution and monitor serum electrolytes, especially potassium, in patients on potassium-sparing diuretics, ACE inhibitors, or with renal/cardio problems 
  • Must be diluted to minimize gastric irritation and avoid mucosal injury 
  • May interact with urinary pH-dependent drugs (e.g., nitrofurantoin) by altering excretion

Product Substitutes

  • Other potassium citrate oral solutions (e.g., Cytra-K, Polycitra-K) For urinary alkalinization: sodium citrate or combined citrate solutions (e.g., Tricitrates SF) 

 Manufacturer/Marketer

In the UK and EU, marketed by generic pharmaceutical companies (UK SmPC). U.S. products (e.g., Potassium Citrate & Citric Acid Oral Solution USP) are manufactured by Pharmaceutical Associates, Inc. (PAI Pharma) .

Country of Origin

Varies by manufacturer:

  • UK/EU generics – manufactured in Europe 
  • U.S. branded solution – made in the U.S. by PAI Pharma

 

Additional information

Additional information

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