Description:
Trox-S 1.5 g is a combipack / injectable antibiotic formulation combining ceftriaxone + sulbactam, used to treat serious bacterial infections by extending the spectrum via β-lactamase inhibition.
Prescription:
Yes — this is a prescription-only injectable antibiotic.
Therapeutic Category:
Antibacterial / antibiotic — cephalosporin (third generation) combined with a β-lactamase inhibitor.
Active Ingredients / Composition:
- Ceftriaxone (presumably 1.0 g)
- Sulbactam (presumably 0.5 g) (making up a total of 1.5 g in the combi pack)
- Excipients (sterile diluent, buffers, etc.) as per formulation (not publicly detailed in the sources I found)
Variant:
Injectable formulation (sterile powder or solution intended for injection). The “combipack” suggests the antibiotic vials plus diluent are packaged together.
Consume Type:
Parenteral — administered by injection (intravenous or intramuscular, as per standard ceftriaxone / sulbactam protocols).
Directions / Usage:
- Administered by a healthcare professional.
- The appropriate dosing frequency and route (IV vs IM) depends on the infection type, severity, and patient status.
- Because the product is a fixed combination, you would follow the prescribing instructions corresponding to ceftriaxone + sulbactam guidelines (e.g. once or twice daily).
- Use in reconstituted form (with supplied diluent) and ensure sterility.
Common Side Effects:
Side effects typical of ceftriaxone/sulbactam combinations include:
- Local injection site reactions (pain, swelling)
- Gastrointestinal disturbances (nausea, diarrhoea)
- Allergic reactions (rash, itching)
- Alteration of liver enzymes or hepatic function
- Changes in blood cell counts (rare)
- Possible superinfection (overgrowth of non-susceptible organisms)
- Potential kidney effects (in susceptible patients)
Package Type:
Combi pack: e.g. vial(s) containing the antibiotic and a 10 mL diluent (sterile water or buffer) for reconstitution.
Storage Advice:
- Store the vials (powder) under controlled room temperature as per label.
- Protect from moisture and light.
- After reconstitution, use the solution promptly (within time limit as specified on insert).
- Keep sterile; do not use if contamination occurs.
Safety Advice:
- Contraindicated in patients allergic to cephalosporins, penicillins, or β-lactam antibiotics.
- Use caution in patients with severe renal or hepatic impairment; dose adjustment may be necessary.
- Monitor for signs of hypersensitivity (anaphylaxis) especially in those with prior β-lactam allergies.
- Be cautious in patients with biliary disease (since ceftriaxone is excreted partly via bile).
- Use with caution in neonates or young infants (depending on local labelling).
- Avoid concomitant use with other nephrotoxic or hepatotoxic drugs without monitoring.
- Ensure proper dilution and administration technique to avoid local tissue irritation or precipitate formation.
- If severe diarrhoea develops (especially bloody), evaluate for Clostridioides difficile infection.
- Do not use beyond the expiry date or if vial integrity is compromised.
Product Substitutes:
- Other ceftriaxone + sulbactam injections (generic combinations)
- Depending on local antimicrobial susceptibility, monotherapy with ceftriaxone (if sulbactam not needed) or alternative broad-spectrum antibiotics as per clinician decision.
Manufacturer / Marketer:
M&G Pharmaceuticals
Country of Origin:
Ghana
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